MiR-26b-3p regulates osteoblast differentiation via targeting estrogen receptor α
نویسندگان
چکیده
منابع مشابه
Estrogen Receptor α Regulates Dlx3-Mediated Osteoblast Differentiation.
Estrogen receptor α (ER-α), which is involved in bone metabolism and breast cancer, has been shown to have transcriptional targets. Dlx3 is essential for the skeletal development and plays an important role in osteoblast differentiation. Various osteogenic stimulators and transcription factors can induce the protein expression of Dlx3. However, the regulatory function of ER-α in the Dlx3 mediat...
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Dickkopf-1 (DKK1) is a powerful antagonist of canonical WNT signaling pathway, and is regarded as a biomarker for osteoporosis. Its expression is highly correlated with bone mass and osteoblasts maturation. In this study, mouse primary bone marrow cells and osteoblast cell lines were used. Luciferase reporter assay and western blotting methods were employed to validate if miRNA-433-3p epigeneti...
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ژورنال
عنوان ژورنال: Genomics
سال: 2019
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2018.07.003